ERS Main Award in Novel Research in Pulmonary Arterial Hypertension

Presented to: Alice Huertas Financially supported by Acceleron

The ERS Main Award offers a €10,000 research grant to the recipient and recognises an awardee who is both a researcher and is pursuing an active research project in the field of pulmonary arterial hypertension.

Alice Huertas

Dr Huertas’ main interests have always centred on pulmonary endothelial dysfunction in pulmonary diseases, and in particular in pulmonary arterial hypertension (PAH). After graduating from Medical School at La Sapienza University in Rome (Italy), she worked as a postdoctoral research scientist in Jahar Bhattacharya’s laboratory at Columbia University (New York, USA), focusing on the inflammatory effects of hypoxia on lung endothelium. Dr Huertas then joined Marc Humbert’s laboratory and was recently appointed as Assistant Professor (Chargé de Recherche) at the French National Institute of Health and Medical Research (INSERM). She practises as a physician at the Day Hospital of the National Reference Centre for Pulmonary Hypertension headed by Professor Humbert.

Dr Huertas is conducting a research program on the interplay between pulmonary endothelial dysfunction and vascular remodelling in PAH. She recently demonstrated a new mechanism in PAH pathogenesis, namely the abnormal overactivation of leptin signalling system in the pulmonary vascular wall, contributing to the disease susceptibility and progression. To better understand the mechanisms by which pro-inflammatory mediators contribute to PAH pathogenesis, she is now focusing on cytokines that signal through class I cytokine receptor family and the intracellular trafficking regulation of these receptors in PAH.

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